ABSTRACT
Objective:To investigate the characteristics of magnetic resonance imaging and clinical application of multi-modality magnetic resonance imaging (MRI) for evaluating the response of neoadjuvant chemotherapy (NACT) in inflammatory breast cancer (IBC).Methods:A total of 36 IBC patients were enrolled in the study.The morphological, hemodynamic and diffusion-weighted imaging features of MRI were analyzed. Eleven patients underwent MRI examination before and after NAT. The imaging changes were analyzed and the efficacy of NACT was evaluated.Results:There were 38 identified breast carcinoma in these 36 cases, among which abnormal skin thickening and enhancement, extensive edema was found in 37 breast lesions. Enhancement of breast lesions in 25 cases was non-mass-like enhancement. Diffusion limitation was found in all lesions. The number of vessels in affected side was more than that in healthy side in MIP images. Thirty three cases had axillary lymph node enlargement.The sensitivity and specificity of MRI in evaluating residual breast tumors and vascular thrombus were high, but the evaluation of axillary lymph nodes was relatively low.Conclusions:Multi-modal MRI can be used for early and accurate diagnosis of IBC. It can also be used to predict and evaluate the effect of neoadjuvant chemotherapy.
ABSTRACT
Objective: Osteoporosis is the well-known major complication in chronic hepatitis B virus [HBV] infection. Fewer reports are available of the relationship between bone loss and chronic HBV infection. We investigated the bone mineral density [BMD] and prevalence of osteoporosis in chronic HBV patients in comparison with healthy subjects
Methods: We assessed 148 chronic HBV patients and 148 age- and gender-matched healthy controls by dual energy X-ray absorptiometry [DEXA] for determination of BMD. T-score was used to define bone status according to the World Health Organization's classification
Results: The BMD values were significantly lower in HBV patients in all scan of specific regions compared with the controls [P < 0.05]. The prevalence of osteoporosis in either of LS, TH or the FN was significantly higher in the HBV patients group compared with the healthy controls. The rate of osteopenia and osteoporosis for HBV patients aged 45-54 years was significantly higher than that of the healthy controls
Conclusions: Chronic HBV infection was associated with low BMD and increased the risk of developing subsequent osteoporosis